香港「青苗」研究計劃（第三期）

Introduction

The School of Public Health is inviting Hong Kong residents aged between 22-50 to join a study to examine how repeat vaccination with two different types of influenza vaccines — namely, the injectable recombinant influenza vaccine and the live attenuated influenza nasal spray vaccine affects the specificity, strength, and form of the antibody response. During the study, participants will be randomly assigned by computer to different study groups and will receive either the injectable influenza vaccine, the nasal spray influenza vaccine, or a placebo (saline) each year.

We will collect blood samples and nasal strip samples before and after the vaccination. Additionally, we will ask you some questions about your health condition after vaccination and we will administer study questionnaires at various time points. The collected samples will be tested for influenza antibody levels, allowing us to assess immune responses to the seasonal flu shot. Participants will receive supermarket voucher(s) at each scheduled visit for the collection of blood samples and nasal strip samples.

The injectable influenza vaccine and nasal spray influenza vaccine used in this study have been registered with the U.S. Food and Drug Administration (FDA) and the local Department of Health, and are used locally.

Study Procedure

• This trial will take place over five years (2025-2030)
• Participants will be randomly assigned by computer to different study groups to receive both injectable injection and nasal spray injection each year. The combinations that participants may receive are:
  (1) Injectable influenza vaccine combined with nasal spray saline "placebo", or
  (2) Nasal spray influenza vaccine combined with injectable saline "placebo", or
  (3) Only saline "placebo" injection
• We will collect blood samples and nasal strip samples before and after the vaccination, and ask you some follow-up questions about the flu shot. The collected samples will be tested for influenza antibody levels, and thus, assessing immune responses to the seasonal flu shot

Benefits of participating

• No cost will be incurred for joining this study
• Participants will receive supermarket voucher(s) at each visit for blood samples and nasal strip samples collection

How do I participate in this study?

Please answer a few questions below and provide your contact information so we can assess your eligibility for the study. We will contact you based on your preferences to provide detailed information about the study and to obtain your informed consent to participate.

Join Now

Contact information of the study team

Study name: DRIVE III Study

We will keep your information, including your contact details, your personal information, or any laboratory testing results strictly confidential in accordance with the University of Hong Kong Privacy Policy Statement. For more details, please click here.